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Lời bài hát Empty Mind – B1A4

Empty Mind - B1A4

Empty Mind - B1A4

Thông tin bài hát

Tên bài hát: Empty Mind
Ca sĩ: B1A4
Sáng tác: unknown
Album: 1st Japanese Album
Ngày ra mắt: 29/10/2012
Thể loại: Nhật Bản, Pop / Dance

 

Lời bài hát Empty Mind – B1A4

Hey
U know my empty mind
U know my empty mind mind

Kanjiru Rhythm & Music Oh party night
Zutto odot te I taku te kedo Time will go
Kimi no sei de kimi no sei de
Boku no kokoro Why I don’t know what to do

Dou shiyou mo nai hodo Baby sagasu Your figure
I’m missing U Oh my lady
Kono mama kono mama sugi te iku no

Marude tsukanoma no yumemi tai
Dakedo yume ja nai
U know my U know my empty mind
Furimuke ba kimi ga iru mitai
Dakedo kimi ja nai
Cause I’m Cause I’m missing
U know my love kitto
U know my heart kimi wa
U know my love shira nai
U know my heart Because my empty mind

Party ga owat te All alone
Korogaru Glass wa Maybe seems like me
Kimi igai wa kimi igai wa
Boku no kokoro Why I don’t want yeah

Omoi o kurikaesu hodo Baby ano jikan wa
I’m missing U Oh my lady
Modot te ko nai no

Marude tsukanoma no yumemi tai
Dakedo yume ja nai
U know my U know my empty mind
Furimuke ba kimi ga iru mitai
Dakedo kimi ja nai
Cause I’m Cause I’m missing
U know my love kitto
U know my heart kimi wa
U know my love shira nai
U know my heart Because my empty mind

D’you know baby
D’you know baby
In my heart shimetsukeru Music
Omoi dasu yo to the touch
Kasanariau to the feeling
Kono mune your sight
I’m on your side
Madowa seru your smile
Ha wasure rare nai yo
This empty mind cmon

Koe o kika se te Baby mouichido odot te Baby
Boku no tonari ni ki te yo Baby
Because of my empty mind

Marude tsukanoma no yumemi tai
Dakedo yume ja nai
U know my U know my empty mind
Furimuke ba kimi ga iru mitai
Dakedo kimi ja nai
Cause I’m Cause I’m missing
U know my love kitto
U know my heart kimi wa
U know my love shira nai
U know my heart Because my empty mind?

U know my love U know my heart
U know my love U know my heart
Because my empty mind

64 thoughts on “Lời bài hát Empty Mind – B1A4”

  59. www.webwiki.nl says:

    Investigations have established that CKD is accompanied by mitochondrial impairment, a
    finding that can also be seen within the elderly [27]. Dynamin-related protein 1 (DRP-1) is
    an indicator of mitochondrial fission that sustains mitochondrial normal situations.
    Microarray analysis of people with CKD, together with those present process hemodialysis, has indicated a compromised
    mitochondrial respiratory perform and consequent oxidative harm [28].
    When C2C12 cells reached 70% confluence, development
    medium was switched to myogenic differentiation medium supplemented with MIF1,
    MIF2, Ac-MIF1, or Ac-MIF2-NH2 for 3 days. Giemsa staining
    was carried out and fusion indices have been determined as we previously
    described [52]. C2C12 cells have been grown in development medium till 70%
    confluent, and then in myogenic differentiation medium (DMEM + 2% FBS + 1% P/S)
    supplemented with MIF1, MIF2, Ac-MIF1 and Ac-MIF2-NH2 for three days to promote myoblast differentiation. Scratch assays are normally used
    to match cell migration parameters such as velocity, persistence, and polarity [31].

    In the muscular tissues, more glucose means extra energy that enhances performance and muscle building.
    It acts on granulosa cells to set off the release of progesterone, minimizing the
    fluctuations in the menstrual cycle. Research focused on follistatin 344 as a potential cancer remedy counsel that it negatively affects sure cancers such
    as the prostate, esophagus, and skin (7). Perhaps, probably the most ground-breaking findings of mice-based research counsel that follistatin 344 may help in some particular types of cancer therapy.
    Some myostatin inhibitors have progressed into medical development
    as summarized in Table 1. There has been progress in evaluating antimyostatin therapies in animal fashions of
    muscle losing issues. Some applications have progressed into scientific
    improvement with initial results exhibiting positive influence on muscle volume.

    We hypothesized that FOR complement would attenuate the decline
    in muscle size throughout immobilization, which would coincide with a discount of
    circulating myostatin and alterations of molecular markers favoring a much less catabolic state.
    Anaerobic energy and anaerobic capacity increased from coaching with no difference between the
    groups. Additionally, although there was an increase
    in the fatigue index over time, no group differences
    had been noticed. The change in peak anaerobic energy observed in this research is analogous in magnitude to
    a earlier research (33). Vera-Ibañez et al. (33)
    studied the effect of high-intensity biking for 4
    weeks on peak energy output through the Wingate check.
    They noticed a rise in peak energy output of ~15% whereas the current study observed an increase of ~11%.

    Targeting this technique may function as an area for developing medication in cachexia therapy and antagonism of melanocortin receptors can current a therapeutic strategy for inflammation-mediated cachexia in CKD.

    It has been reported that central blockade
    of MC4-R might reduce uremic cachexia in experimental animals [11, 21].
    The administration of agouti-related peptide (AgRP)- an MC4-R
    antagonist- in mice with CKD, led to the augmentation of food intake, regulation of basal metabolic fee, in addition to the enhancement of total
    physique weight and lean body mass. Therefore, AgRP administration improves uremic cachexia with out nutritional effects by involving muscle mass modulation by way of myostatin and IGF-I stability [9].
    Muscle mass will increase by IGF-I whereas myostatin inhibits muscle mass development [146].
    Cheung and coworkers assessed the protecting effect of pegylated leptin receptor antagonist (PLA) in cachectic mice with CKD.
    Their outcomes indicated that PLA treatment (7 mg/kg per day) might increase
    urge for food, weight gain, lean mass as properly as muscle
    operate, along with decreasing energy expenditure, and recovering hepatic levels of TNF-α
    and IL-6 mRNA.
    Ever since its discovery, intensive research
    has been carried out to suppress the exercise of MSTN utilizing soluble activin kind IIB (sACVRIIB) receptors, peptides or propeptides, small
    molecules, neutralizing antibodies, or MIPs (Table 1).
    Based in Canada, Katrina is an skilled content author and editor specializing in well being and wellness.
    With a journalistic approach, she’s crafted over 900,000 words on supplements, striving
    to debunk myths and foster a holistic approach to healthi…
    Although epicatechin and quercetin are considered secure dietary supplements, don’t
    go all in without doing your personal analysis. If you are on drugs or have a health condition, this implies speaking together with your healthcare skilled to ensure it is applicable
    for your fitness objectives. By doing this, you could make
    more knowledgeable decisions, maximizing your efforts whereas
    safeguarding your well being.
    After the 5 min warm-up period, topics continued to warm-up for a further 20 s adopted by a 6 s
    acceleration phase, throughout which they pedaled as fast as attainable against no resistance to attain peak
    cadence. Immediately on the end of this section,
    a load equal to 7.5% of bodyweight was utilized to the flywheel and topics pedaled as
    fast as possible for 30 s. Information was recorded and saved utilizing the Velotron Wingate
    software program (Racer-Mate, Seattle, WA). The EPI group consumed one
    capsule containing a hundred mg of 98% pure (–)-epicatechin twice every day (200 mg total).
    Participants had been instructed to devour one 100 mg capsule in the morning
    and one a hundred mg capsule within the afternoon or night.

    The key attribute of cachexia is a weight loss of more than 5% in the earlier 12 months or a BMI
    (body mass index) of lower than twenty kg/m2. However, within the case
    of CKD, as a outcome of an inclination for elevated
    physique weight in affected patients, detecting low BMI would not be a great choice resulting in a late prognosis, even though it is a valid and delicate method
    to manage cachexia [13, 17]. In protein–protein docking,
    the power of interaction between two proteins is measured by means of global energy with a excessive (negative) global power value
    considered because the interplay effectivity of a protein with its receptor [18,30].
    In this research, MSTN interacted with ACVRIIB
    with a worldwide power of −61.sixty three, while MSTN–MIF1
    and MSTN–MIF2 interacted with world energies of −59.69 and −53.ninety one,
    respectively. These variations between international energies indicate that MIF1 and MIF2 weakened MSTN–ACVRIIB binding.

    Astragalus polysaccharide (APS; also called Huang
    Qi) is a well known extract of Astragalus membranaceus
    (Fisch.) Bge (AMB) (Fu et al., 2013). Like different members of the pro-TGF-β superfamily, pro-MSTN is a
    homodimer comprised of two identical disulfide-linked subunits.
    Every chain consists of 109 amino acid residues containing a pro-domain (N-terminal) and
    a smaller progress factor (GF) domain (C-terminal). As found in different members
    of the TGF-β superfamily, the GF area of MSTN contains a
    cystine-knot motif and four antiparallel β-strands known as “fingers”.
    The two identical GF domains of MSTN are linked by their concave “palms”, which are covalently linked to one another by disulfide bonds between C339 residues within the wrist region.
    It helps improve muscle development and recovery, they usually report better exercises total.

    Dietary fibers, metabolized into SCFAs by gut flora, contribute to body weight regulation by
    enhancing expenditure of vitality, appetite regulation, and optimizing the metabolic process of fats tissue and muscle mass in individuals with extra weight [175].
    Computer-aided drug design (CADD) and computer-assisted molecular design (CAMD) are used as drug discovery instruments in the pharmaceutical science subject (Baig et al., 2016).
    VS. is extensively used for drug discovery and is complemented by Excessive
    Throughput Screening (HTS).
    This flavonoid is synthesized within the human guts after consumption of foods rich in ellagitannins (like pomegranate, Punica Granatum) and is a robust
    anabolic that ​stimulates muscle progress whereas concurrently stopping
    muscle breakdown. Though no human trials have confirmed
    these outcomes, animal-based studies recommend that follistatin can reduce the
    life and development of most cancers cells and minimize
    the possibilities of metastasis (4). Nevertheless, in men, higher levels of follicle-stimulating hormone
    (FSH) restrict muscle development and cause abnormal testicle functioning.

    Unbound Epicatechin is known as a muscle amplifying agent because this
    complement will assist enhance your general muscle growth.

    The effect on skeletal muscle development is one
    of the primary reasons for the massive interest for
    epicatechin in recent times. One study was capable of decide that
    epicatechin from dark goodies inhibits myostatin. Low levels of myostatin protein are fascinating as a result
    of it leads to increased capability to build skeletal muscle mass.
    Phenolic compound resveratrol has anti-inflammatory and
    antioxidant properties that encourage the production of more antioxidant-related enzymes
    and activate transcription elements like NRF2 [189].
    As a outcome, it might hinder the degradation of proteins, which is
    primarily caused by the angiotensin I and II routes, and phorbol ester by way
    of minimizing the expression of MAFbx, MuRF1, and NF-κB [190].
    Furthermore, elevated NRF2 gene expression has been linked to the
    regulating of pro-inflammatory cytokines, primarily IL-6 and TNF.

    While myostatin inhibitors like peptides and SARMs are
    gaining reputation, you can also lower your myostatin levels naturally
    via foods and supplements. And while the evidence is either anecdotal
    or comes from animal fashions, these pure options are still a great place
    to start. Myostatin, also called development differentiation factor eight (GDF-8), is a member of
    the TGF-beta superfamily. Whereas that sounds like the other of
    what you’re in search of in your health
    story, myostatin truly plays a crucial role in maintaining muscle homeostasis and stopping uncontrolled development.

    The excellent news is that EGCG could be enzymatically transformed into its
    constituent molecules — epicatechin and gallic acid — that
    are readily absorbed, stable at various pH ranges, and seemingly much more beneficial for longevity and athletic efficiency [7].
    With that in thoughts, let’s take a look at the analysis behind
    epicatechin dietary supplements as ergogenic aids. If you’ve ever taken a green tea leaf extract
    complement, odds are you are conversant in EGCG.
    They are continually monitored by our inside peer-review process and if we see anyone making material science errors,
    we do not allow them to write for us once more. SelfHacked has the strictest sourcing guidelines within the well being industry and we almost exclusively hyperlink to medically peer-reviewed
    research, normally on PubMed. We imagine that the most correct information is found instantly
    within the scientific supply. While options like SwissChems Myostatin 1 mg and PureRawz
    Myostatin ship noticeable outcomes, in addition they carry risks.
    It’s vital to pair any supplementation with a stable fitness routine, balanced diet, and skilled guidance.

    The supplements had been provided pre-mixed right into a chocolate pudding to match the flavour and texture to take care of blinding.
    Epicatechin is a pure plant compound from a robust group
    of phytochemicals often identified as flavanols.
    Consuming foods wealthy in epicatechin as well as
    adding a excessive quality epicatechin supplement might allow you to boost circulation, improve your coronary heart health, promote muscle development, and even defend
    you in opposition to age-related muscle wasting and other health problems.

    As a natural anabolic compound, laxogenin stacks properly with epicatechin to
    boost muscle development. Two serum separation vacutainer tubes and one EDTA vacutainer tube was obtained from every topic.
    The serum vacutainers had been separated by way of centrifugation a 6,000 rpm for 20 minutes.
    One serum separation tube and the EDTA tube had been sent to Quest Diagnostics
    (Dallas, TX) for assay of a standard scientific chemistry profile and entire blood cell counts to ensure safety of supplementation through the protocol.

    Skeletal muscle is a receptor tissue for androgens that positively influence muscle resilience,
    hypertrophy, and regeneration [91]. Testosterone enhances muscular anabolism, accelerates protein era, prevents muscle
    breakdown, and boosts the effectiveness of amino acid reutilization in muscles [92].
    Over 60% of people with extreme CKD exhibit decreased blood
    concentrations of testosterone, which may set off muscle atrophy
    by modifying IGF-1 signaling and elevating myostatin quantities [92].

    Moreover, feminine people with CKD have estrogen scarcity within the first
    section of the situation, and diminished estrogen concentrations correlate with decreased muscular power and functionality [81].
    In a murine model of CKD, parathyroid hormone and its receptor signaling in fats tissue induce dysregulated thermogenesis and hypermetabolism, resulting in muscle loss
    [86]. Consequently, human ranges of hormones also have
    a job in muscle atrophy among individuals with CKD.
    In addition to antagonizing the myostatin ligand, concentrating on its receptors to dam the signaling transduction pathway has also been extensively explored as a remedy strategy for muscle-loss issues.

    The samples had been then centrifuged at 3000 rpm for 10 
    min at four °C to collect the supernatant. The ranges of the neurotransmitters acetylcholine (ACh), glutamate (Glu), gamma-aminobutyric acid
    (GABA), and serotonin (5-HT), which are associated to fatigue, were measured utilizing
    ELISA following the manufacturer’s directions. The absorbance at 550 nm and 340 nm was measured using a
    spectrophotometer or microplate reader. The kits used on this examine have been evaluated for consistency of efficiency throughout
    totally different batches of kits by restoration checks with recoveries ranging from 90%-110%
    and calibrated by standards. The tools used had a measurement accuracy of zero.01% and was
    calibrated before every experiment. Ltd.
    (Wuhan, China), and cultured in DMEM supplemented with 10% FBS
    and 1% penicillin/streptomycin (Cell-specific DMEM; Procell, Wuhan, China) in an incubator at 37 °C with
    5% CO2.
    Transgenic overexpression of FST leads to a 2- to 3-fold increase in muscle mass
    via hypertrophy and hyperplasia [21]. However,
    the rise in muscle mass just isn’t solely attributed
    to blocking MSTN, as FST additionally inhibits the activities of
    multiple TGF-β family members, some of them play a task in limiting muscle mass [76].
    FST-overexpressing MSTN-null mice show an much more excessive fourfold increase in muscle [77].
    Contrarily, FST-null mice have decreased muscle mass at start and perish
    within a quantity of hours [78]. Supply of
    FST-coding mRNA gene therapy and AAV, in addition to follistatin peptide derivatives, have all been proven to
    supply substantial muscle enhance in animal fashions [35, 79, 80].
    Scholar Rock has submitted its anti-myostatin antibody
    apitegromab for FDA approval, just months after reporting that
    it hit its primary endpoint in section III for spinal muscular
    atrophy (SMA). Approval would upend two decades of failure for
    myostatin pathway inhibitors, a class of medication that grows skeletal muscle.

    In section 2 trials with boys affected by DMD, weekly doses of taldefgrobep alfa led to a modest 4.9% increase in lean body mass index within the pooled therapy group in comparison with
    placebo, but ultimately found no change in motor perform [69].
    Further research focused toward DMD has been terminated, but a section three study evaluating taldefgrobep alfa in SMA is at present underway.
    MSTN is primarily expressed in skeletal muscle however can additionally be expressed to a lesser extent in adipose tissue [15], coronary heart [16],
    and kidney [17]. Like most other members of the TGF-β household,
    MSTN is secreted as an inactive precursor, comprised of an N-terminal signal peptide,
    N-terminal propeptide, and C-terminal development
    issue (GF) area [18].
    The number of myostatin-positive SC–myostatin inhibits
    the progress of SC into the S phase of the cell cycle
    [9]–increased after 2 weeks of immobilization in each
    teams. More studies are needed to find out the connection between disuse-atrophy and myostatin-positive
    SC. Nonetheless, it was consistent with the earlier examine reporting the blunted response of the decline in the variety of myostatin-positive SC to resistance train in older adults, who
    could have an impaired myogenic capability in comparison with young [34].

    This disparity in MSTN availability may contribute to a shift in potency between species.
    A pharmacokinetic research with MYO-029 found that the concentration of MYO-029 required to
    elicit a 50% enchancment in muscle mass in monkeys was
    18 occasions higher compared to the same enchancment in mice [107].
    This discrepancy in pharmacokinetics and MSTN serum focus between diseased
    human and mouse models could considerably contribute to the distinction in results
    between scientific and animal trials. Inhibiting further ligands that sign via the primary myostatin receptor may
    protect in opposition to muscle loss. Myostatin is known to signal by way of transmembrane activin Kind IIB receptors (ActRIIB) together with Activin A and different ActRIIB ligands28,34.

    Individuals claiming the capacity to lift larger weights have
    reported improved performance in exercises similar to bench presses.
    Some users have even claimed deadlift improvements of as much as 50 pounds while using YK11.
    Promising to boost absorption of epicatechin by as a lot as
    200 to 600%, Ep1logue by Olympus Labs guarantees to help enhance circulation to your muscle tissue during your workouts for optimal vascularity, vitality, and performance.

    Reviewers have noticed optimistic results
    with a selection of training stimuli and rep ranges.

    There have been nearly no epicatechin unwanted side effects reported within the literature, so it is considered a protected supplement for any wholesome grownup, including
    ladies. Women, just be sure to select an epicatechin supplement that’s freed from any testosterone boosters.

    We would like to thank the subjects that participated in this examine and the laboratory assistants in the Train & Sport
    Nutrition Lab (ESNL) who assisted with knowledge assortment and evaluation.

    References:

    what are the negative effects of steroids (http://www.webwiki.nl)

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